Evoke Neuroscience awarded Breakthrough Technology agreement with Premier

New York, NY, March 29, 2018 – Evoke Neuroscience has been awarded a group purchasing agreement as a breakthrough technology with Premier. Effective March 1, 2018, the agreement allows Premier members to take advantage of special pricing and terms pre-negotiated by Premier for the eVox® System, the medical device that assesses brain function to aid doctors in the diagnosis of cognitive disorders.

“We are thrilled to be recognized by Premier as a Breakthrough Technology,” said John Armstrong, Executive Vice President of Sales at Evoke Neuroscience. “This Technology Breakthroughs contract recognizes the innovative way that the eVox System aids primary care physicians in their diagnosis of patients with memory loss and other cognitive disorders.”

Historically, most providers have relied on self-report questionnaires and effort-based computerized testing for determining a diagnosis. But to understand cognitive health, and more specifically memory, it is important to measure key biomarkers of the brain itself. The eVox® System fulfills the need for objective memory-related biomarkers that aid in the diagnosis of cognitive diseases such as dementia.

Primary and specialty care physicians can use eVox® to acquire these biomarkers in-house via a non-invasive procedure performed with minimal staff training and time. Doctors should use their professional judgment in determining when the eVox® System is appropriate to aid in diagnosis.

Premier is a leading healthcare improvement company, uniting an alliance of approximately 3,900 U.S. hospitals and 150,000 other providers to transform healthcare. With integrated data and analytics, collaboratives, supply chain solutions, and advisory and other services, Premier enables better care and outcomes at a lower cost.

About Evoke Neuroscience

Evoke Neuroscience (www.evokeneuroscience.com) was formed in 2009 with the mission to improve diagnosis and treatment of cognitive disorders with objective, clinically meaningful and easy-to-use products. Physicians use the eVox® System to assess brain health and aid in the diagnosis of memory loss and other cognitive disorders.

Evoke Neuroscience announces award of VA contract for the eVox® System

Evoke Neuroscience, Inc. is pleased to announce the award of a Veterans Health Administration Contract for the eVox® System. The Contract award #36F79718D0348 enables the VA and other federal organizations to purchase the eVox System at pre-approved pricing via the Veterans Administration’s FSS Contract, via GSA Advantage, or GSA eBUY.

The eVox System measures brain health to aid doctors in the diagnosis of cognitive disorders. By measuring brain function directly, physicians can enhance their clinical work-up beyond standard subjective patient questionnaires. eVox provides clinically actionable and objective biomarkers of brain health pertinent to conditions like Alzheimer’s disease, mild cognitive impairment, and other cognitive disorders.

Evoke has a long history in supporting military personnel and veterans with their cognitive health needs.  The company was borne out of work done to treat PTSD and TBI at the Marine Corps Base in Camp Lejeune nearly 10 years ago. “With this FSS contract, we can now deliver our technology to more of those who have served,” explained Evoke Neuroscience CEO David Hagedorn, Ph.D. “We strive to improve the diagnosis and treatment of brain disorders for patients throughout the country – and veterans are among those who need us most. We are exceptionally proud to offer our eVox System to the Veterans Administration Health System and the U.S. Military Health System.”

About Evoke Neuroscience, Inc.

Evoke Neuroscience (www.evokeneuroscience.com) was formed in 2009 with the mission to improve diagnosis and treatment of cognitive disorders with objective, clinically meaningful and easy-to-use products. Physicians use the eVox® System to assess brain health and aid in the diagnosis of memory loss and other cognitive disorders.

Evoke Neuroscience named to Inc. 5000 List of America’s Fastest-Growing Private Companies for Second Consecutive Year

For the second consecutive year, Evoke Neuroscience was ranked on Inc. magazine’s annual Inc. 500|5000, an exclusive list of the nation’s fastest- growing private companies. Market leader in brain assessment and training technology, Evoke Neuroscience was recognized in 2017 for achieving an impressive three-year growth rate of 537%.

“Evoke Neuroscience is honored to be named to the Inc. 5000 list for the second consecutive year,” said Evoke Neuroscience CEO and co-founder, David Hagedorn, PhD. “To be included in this list is a significant achievement for Evoke and we are proud to be recognized for doing our part to spur innovation, create jobs, and drive the economy forward.”

On average, the 2017 Inc. 5000 honorees achieved a three-year average growth of 481%. The companies boast an aggregate revenue of $206 billion and collectively generated 619,500 jobs over the past three years.

“We believe that everyone should have access to affordable and easy-to-use tools that measure and train brain health. Evoke’s clinical solutions are making this dream a reality for patients throughout the country – from patients with cognitive concerns to elite athlete peak performance training and the military, including the US Special Operations Forces.” Evoke Neuroscience co-founder and Chief Strategy Officer, James Thompson, PhD, explained. “Our steady, consistent growth as a company fortifies our mission to improve patient health and quality of life by bringing medical neuroscience out of the laboratory and into the physician’s office.”

Learn more about Evoke Neuroscience’s state-of-the-art hardware/software system that objectively measures and trains the brain. For more information, contact Evoke Neuroscience at info@evokeneuroscience.com.

About Evoke Neuroscience

Evoke Neuroscience (www.evokeneuroscience.com) was formed in 2009 by research scientists, clinicians, medical doctors, and business professionals dedicated to developing and delivering the most important advances in brain science. Evoke Neuroscience believes that improving patient health starts with the brain. Their flagship product, the eVox® System, is an accessible, affordable, and easy to use tool that empowers primary and specialty care physicians to objectively measure and train the brain.

About Inc.

The Inc. 5000 is a list of the fastest-growing private companies in the nation. Started in 1982, this prestigious list of the nation’s most successful private companies has become the hallmark of entrepreneurial success. The list represents a unique look at the most successful companies within the American economy’s most dynamic segment— its independent small and midsized businesses. Companies such as GoPro, Oracle, Square, Timberland, Microsoft, Dell, Pandora, Timberland, and many other well-known names gained their first national exposure as honorees of the Inc. 5000.

Inc. 500|5000 Methodology

The 2017 Inc. 5000 is ranked according to percentage revenue growth when comparing 2013 to 2016. To qualify, companies must have been founded and generating revenue by March 31, 2013. They had to be U.S.-based, privately held, for profit, and independent—not subsidiaries or divisions of other companies—as of December 31, 2016. (Since then, a number of companies on the list have gone public or been acquired.) The minimum revenue required for 2013 is $100,000; the minimum for 2016 is $2 million. As always, Inc. reserves the right to decline applicants for subjective reasons. Companies on the Inc. 500 are featured in Inc.’s September issue. They represent the top tier of the Inc. 5000, which can be found at http://www.inc.com/inc5000.

Brain training: Bogus or brilliant? Well, it depends…

We have all seen the advertisements: train your brain for better memory, learning, and power! Cognitive training is one of the hottest new trends in self-improvement. And, if you have been misplacing keys or regularly missing appointments, it may be tempting to sign up for these “brain games”. The hope that after a few weeks of puzzles your brain will be churning out names, dates, and cell phone numbers like you are 17 again is indeed a tempting lure.

The question is: Does brain training really work? As the number of cognitive training interventions grow, researchers have come to understand that there are in fact approaches that do work, while others do not1. Thus, not all brain training is created equally. Before you invest your time and money in a brain bootcamp program, it is important to identify a cognitive training strategy that is the best fit for you.

Here are 2 points to consider:

1. What goals do you hope to achieve from brain training?
There is no right or wrong reason for wanting to enhance our brain function – everyone has room for improvement! But, the specific goals you have set for yourself might be better achieved through certain types of cognitive training compared to others.
Dust off the cobwebs
Perhaps you are striving to break the TV binge-watching habit and are looking for fun and engaging ways to mentally get off the couch. If this is the case, brain games like Sudoku, crossword puzzles, quizzes, and word problems might be the way to go. These are not truly “brain training”, but instead are “brain games”. They can help you dust off any mental cobwebs, but will not create a global improvement in brain function.
Proactive prevention
Or, you might be seeking out cognitive training tools to improve your working or short-term memory. This is no surprise – as we live longer, we are faced with the need to fend off cognitive decline for as long as possible. Research tells us that the best way to prevent symptoms of aging, neurodegeneration, or cognitive decline is to improve brain performance in a sustained manner2. Many brain training programs boast exercises “proven” to boost brain benefits. But, if these exercises are merely proven to improve your performance on a specific task type, they will not generalize into real-life situations. These exercises often fall into the “brain games” category, discussed above, and are not true brain training paradigms. Read carefully about these cognitive training programs and ensure that scientific evidence shows a generalization of brain benefits.
Doctor recommended
Alternatively, perhaps your doctor suggested you consider a cognitive training program to help treat a disease. In these cases, brain training is “prescribed” by your doctor. Biofeedback, neurofeedback, and brain stimulation (in the form of tDCS – transcranial direct current stimulation3) are increasing in popularity as approaches to brain training. They are inexpensive and safe techniques that have been increasingly shown to enhance or normalize brain functions. In fact, a growing number of general practice physicians are adding medical treatments and resources such as these for patients who wish to improve cognitive function. Of course, how you use these techniques will affect the outcome of training. Working closely with your doctor can help ensure that your brain will get the individualized training it needs.

2. Are you willing to commit to brain training?
Brain training to improve cognitive function in a sustained manner is more than just mental activity, it is mental exercise. And like physical exercise, mental exercise should train as many “muscles” as possible. This means incorporating novelty, variety, and challenge into your training paradigm and cross-training a variety of intelligence capacities, like emotional, executive, and perceptual skills4.
Just as you wouldn’t expect to derive lifelong benefits from running a marathon tomorrow and then not exercising ever again, you should not expect lifelong benefits from a one-time brain training activity. True cognitive training programs are no quick fix for a healthier brain. For the desired cognitive boost, an effective training program should be individualized, adapt to performance, require effortful attention, increase in difficulty, and be performed systematically.

It will take effort, but don’t shy away from the challenge! Pick the best type of brain training to accomplish your goals, and stick with it. Your brain will thank you for your hard work.


1 Melby-Lervag, M., Hulme, C. (2013). Is working memory training effective? A meta-analytic review. Developmental Psychology, 49 (2): 270-291.

2 Willis, S., Tennstedt, S., Marsiske, M., et al. (2006). Long-term Effects of Cognitive Training on Everyday Functional Outcomes in Older Adults. JAMA, 296 (23): 2805-2814.

3 Gill, J., Shah-Basak, P., & Hamilton, R. (2015). It’s the Thought That Counts: Examining the Task-dependent Effects of Transcranial Direct Current Stimulation on Executive Function. Brain Stimulation, 8 (2): 253-259.

4 Kueider, A., Parisi, J., Gross, A., Rebok, G. (2012). Computerized Cognitive Training with Older Adults: A Systematic Review. PLoS ONE 7 (7): e40588.

Medical brain tech company Evoke Neuroscience ranked by Inc. 500 as one of America’s fastest growing companies

Inc. magazine ranked Evoke Neuroscience No. 131 on its Inc. 500, an exclusive ranking of the nation’s fastest-growing private companies. Market leader in brain assessment and training, Evoke Neuroscience made the list by achieving a three-year growth rate of 2,638%.

“This recognition fortifies our mission to improve health and quality of life with cognitive improvement tools that are accessible, affordable, and easy to use. We are proud to be recognized for doing our part to spur innovation, create jobs, and drive the economy forward,” said David Hagedorn, PhD, co-founder and CEO. “We share this honor with our loyal customers, dedicated partners and talented employees.”

As a 2016 honoree, Evoke Neuroscience now shares a pedigree with GoPro, Oracle, Zappos, Square, Timberland, and other notable alumni that gained early exposure as members of the Inc. 500.

Evoke Neuroscience co-founder and Chief Strategy Officer James Thompson, PhD, attributes the company’s success to a passion for making medical neuroscience easily accessible. “We believe that everyone should have access to tools that gauge and improve their brain health and function. Evoke’s clinical solutions help patients with a variety of cognitive concerns. But they extend far beyond the physician’s office – from peak performance training of elite athletes to the military, including the US Special Operations Forces.”

Inc. unveiled its 35th annual Inc. 5000, with the top 500 companies also featured in the Inc. 500 and the September issue of Inc. magazine. Collectively, this year’s top 500 companies have created more than 55,000 jobs, earned $13.8B total revenue, and achieved an impressive median three-year growth rate of 1,581%.

About Evoke Neuroscience
Evoke Neuroscience (www.evokeneuroscience.com) was formed in 2009 by research scientists, clinicians, medical doctors, and business professionals dedicated to developing and delivering the most important advances in brain science. Evoke Neuroscience’s goal is to improve people’s health, performance, and quality of life with cognitive tools that are accessible, affordable, and easy to use.

About Inc. 500|5000 List
The Inc. 500|5000 List showcases the fastest growing, privately-held companies in America. Started in 1982, this prestigious list of the nation’s most successful private companies has become the hallmark of entrepreneurial success. Companies are ranked according to the percentage growth of their annual revenue over a 3 year period; the 2016 Inc. 5000 is ranked according to percentage revenue growth when comparing 2012 to 2015. Complete results of the Inc. 500|5000 can be found at http://www.inc.com/inc5000/.

Evoke Neuroscience recognized as key innovator in advancing transformative technology for mental wellbeing


Evoke Neuroscience has been featured in the first-ever TransTech 200 list for advancing technology for mental and emotional wellbeing. TransTech 200, curated by the Transformative Technology Lab, is the first list to highlight pivotal innovators, influencers, organizations, scientists, and entrepreneurs who are expanding the known limits of human thriving.  “We are grateful to be recognized for the work we do in the space,” said David Hagedorn, Ph.D., Evoke Neuroscience co-founder and CEO. “We are honored that our effort to bring functional neuroimaging to the physician’s office in an easy-to-use, objective, and cost-effective way is recognized as innovative and influential. Our focus is on improving human health and wellbeing, and that starts with the brain.” Awarded for innovation in the category of Neurofeedback, Evoke Neuroscience creates cutting edge technology that allows physicians to evaluate patient brain health and to train the brain in order to achieve healthier functioning. As a TransTech honoree, Evoke Neuroscience now shares a pedigree with DARPA, Google, Fitbit, HeartMath, and other notable companies and scientists on the 2016 list.

About Evoke Neuroscience
Evoke Neuroscience was formed in 2009 by research scientists, clinicians, medical doctors, and business professionals dedicated to developing and delivering the most important advances in brain science. Evoke Neuroscience’s goal is to improve people’s health, performance, and quality of life with cognitive tools that are accessible, afordable, and easy to use.

About TransTech 200 List
The TransTech 200 is the annual list of the key innovators who are driving technology for mental and emotional wellbeing forward. The list is open to both individuals and organizations who are making significant contributions via Transformative Technology research, creation, and/or distribution. Complete results of the TransTech 200 can be found at http://transtech200.com/.

How biofeedback games can rewire your brain.

The US has seen an increase in conditions that impact brain health; 48% of Veterans returning from combat who seek VA treatment are diagnosed with a mental health problem. The rate of reported sports-related concussions has doubled in the past decade. And diagnoses for neurological disorders such as ADHD and dementia have been steadily increasing.

Though there are cases in which medication is absolutely necessary, there are growing concerns about the rapid rise and abuse of psychotropic prescriptions without a proper evaluation by a mental health professional. Dr. James Thompson of Evoke Neuroscience spoke to Hopes&Fears about how biofeedback training can help rehabilitate the physiological changes resulting from traumatic brain injuries.

A physiological approach

In 2009, Doctors James Thompson and David Hagedorn founded Evoke Neuroscience with exactly this goal in mind. Specializing in traumatic brain injuries caused by sports injury and military trauma respectively, both Thompson and Hagedorn were using electrophysiology as a measurement tool to see how the injury was affecting brainwaves and heart rate patterns and figure out how they could recover normal functioning. “A lot of medications deal with symptoms [of traumatic brain injury] but aren’t actually treating the root causes of the symptoms,” Dr. Thompson tells Hopes&Fears. “The anxiety, the depression, the sleep disorders—they’re all a result of physiological changes in your brain.”

Medication can provide supplementation or re-uptake certain chemicals that cause these symptoms, but take away the medication and the chemical processes still haven’t been cured. Instead, Evoke uses brain processing speed measures, cardiac measures and neuropsychological testing to target parts of the brain which aren’t functioning properly, and then uses neurofeedback to train the neurons back to health. “By doing EEG neurofeedback training, you’re teaching the neurons to release chemicals and to communicate in specific patterns. And by reinforcing those patterns, the neurons actually learn to communicate in a process called long-term potentiation,” Thompson explains. “The saying is, ‘the neurons that fire together, wire together.’”

The problem, Thompson says, is that this information is hard to collect, requiring data collection using multiple measurement systems and hours of cross-specialty analysis. So while neurofeedback and heart rate variability (HRV) training have been shown in a multitude of peer reviewed literature publications to be effective in remediation the negative effects of central and autonomic nervous system trauma such as concussion and PTSD, the roadblocks in knowledge and access keep physicians from practicing them. What Evoke has developed is a system that puts all of the software, hardware and education in one accessible, easy-to-use place. “We thought, ‘wouldn’t it be cool to get access to this type of information to more practitioners?’” Thompson recalls. “Instead of two hours just to collect the data, our system can do it in just 20 minutes.”

The Evoke team also provides a multifaceted education program with training manuals, bi-monthly live webinars and over 250 research references so that doctors can read the original studies behind specific parts of their tools. “It’s like a specified internet,” Thompson jokes, “we brought all the information together so they don’t have to go searching for multiple hours.”

How it works

The Evoke system is a portable brain-computer interface that allows physicians to assess the extent and specific locations of brain injury by conducting EEG readings using a special device fondly called the “Michael Phelps” due to its swim cap-like appearance. Heart and breath rate are also measured, giving the physician a full picture of a patient’s central and autonomic nervous systems. With a report in hand, the physician can create a training program that targets those specific brain areas that are not performing optimally to get them to “fire and wire” together. “When the neurons in those regions start firing the way we want them to, the person gets rewarded by an auditory sound or visual cue that basically says, ‘good job,'” Thompson explains, “by getting that reward, chemicals are released and the neurons learn to uptake those chemicals, which is reinforced by doing the training over and over again.”

Take your typical concussion patient. Traditionally, related symptoms such as chronic headaches and sleep disorders are treated using medication with hopes that patients can cope with the symptoms long enough for the concussion to resolve itself. But with Evoke’s system, a doctor can identify the physiological problems and prescribe treatment that actually resolves the functional damage caused by the concussion. So if the patient is experiencing sudden difficulty with their emotional regulation, for instance, a doctor can check for frontal lobe functionality, which deals with emotional regulation, and assess whether it’s functioning optimally. Or if the patient is complaining of headaches, a physician can measure heart rate variability which, when unbalanced, can affect blood flow, thus causing headaches. With this information, a physician can target neurofeedback training to the frontal lobe or set up an HRV program to re-regulate blood flow. Combined with proper medications and supplements, the Evoke system rounds off a holistic approach toward rehabilitation.

Typically patients will do neurofeedback training an average of three days a week, in about twenty to forty sessions running about 30 minutes each. “Your brain is plastic, meaning it can change,” Thompson explains, “by training it and exercising your brain it literally changes to meet the criteria you set for it. So in training, your brain is learning the patterns that are more normal.” Patients are also provided with a wristband and training app that goes home with them so they can train between scheduled doctor’s visits, much like the prescription model that practitioners are already used to.

Tried, tested and true

The spectrum of patients who can benefit from biofeedback training is remarkably broad, from young people with ADHD, to athletes with sports injuries, to professionals working in high-stress environments suffering from crippling anxiety and sleep disorders as a result. Physicians using Evoke’s technology also see a lot of Veterans suffering from psychophysiological disorders resulting from PTSD, as well as older people experiencing mild cognitive impairment that comes naturally with age or who use HRV rehabilitation after a cardiac event. “There’s a lot of research demonstrating a significant reduction in the likelihood of a second heart attack if you do HRV training after your first heart attack,” Thompson points out.

Though Evoke is in no way proposing that biofeedback training can completely replace medication, there is no doubt that the system is an effective rehabilitation tool. “In terms of whether the technology we’re developing is going to be helpful, we know that it will. We didn’t invent HRV training or brainwave analysis or neurofeedback,” notes Thompson. “Those all existed already; brainwave patterns were discovered in 1924 by Hans Berger. Neurofeedback and the ability to train specific patterns and change brain functioning has been around since the 1960s. We didn’t invent anything. All we did was make it accessible, easy and understandable.”